The cellular diversity of the human brain is immense, which is generated through evolutionarily conserved developmental mechanisms. The system is robust enough to create functional masterpiece; yet is susceptible to failure that may lead to cognitive dysfunction
We aim to delineate the molecular and cellular mechanisms behind cell fate decisions of neural stem cells and how these mechanisms fail in mutations associated with autism spectrum disorder (ASD). A secondary goal of our lab is to determine how histone methylation contributes to the cellular heterogeneity in the adult brain. We use state-of-the art single cell sequencing techniques, CRISPR-mediated gene inactivation, mouse genetics and computational tools to run multidisciplinary, collaborative projects
Ongoing research can be described in two questions:
- How do ASD-linked histone modifiers affect cell fate choices of neural stem cells?
- How does histone methylation contribute to cellular heterogeneity in the adult reward system?