Leptin is a hormone that is secreted by fat and signals the need to stop eating and increase energy expenditure via leptin receptors (LepR). Various hunger and reward centers in the brain contain different LepR expressing neurons. The primary leptin center is the well-studied arcuate nucleus. Other hypothalamic nuclei are less abundant in leptin receptorContinue reading “Leptin targets spatially diverse neurons”
Category Archives: news
Single-cell profiling adult human neural stem cells
Single cell characterisation of neural stem cells of the adult human subventricular zone identifies SFRP1 as a quiescence signal
New PhD course from the UMC Brain Center
Translational Neuroscience Department at the Triathlon from HandicapNL
On the 25th of August, Saturday, We are participating the team Triathlon from HandicapNL as the Translational neuroscience department, with 5 teams!! You can support us by donating through the website below: https://evenementen.voorhandicap.nl/team/neurosport
6th International Congress of the Molecular Biology Association of Turkey (2-8 September 2018) will take place in Izmir
Thanks to the kind invitation of the organisers, I will be participating to the annual meeting of the Molecular Biology Association of Turkey as an invited speaker. The talk will take place on the 6th of September, 15:30. Looking forward to it! http://www.ibg.edu.tr/molbiyokon18
iBrain Lecture: Reconstructing neural hierarchies cell by cell (Düsseldorf, Germany)
Date / Time: 13.06.18 / 08:30 – 09:30 Location: Lecture Hall Neuropathology, Düsseldorf Universität, Germany
Dissecting Hematopoietic stem cell fate using Ki67-RFP knock-in mouse line
Congrats to Tatyana Grinenko and Ben Wielockx from Dresden, Germany! The collaboration we initiated around 2 years ago, using the Ki67-RFP mouse line to identify and purify dividing blood stem cells, is now a part of the recent Nature Communications article “Hematopoietic stem cells can differentiate into restricted myeloid progenitors before cell division inContinue reading “Dissecting Hematopoietic stem cell fate using Ki67-RFP knock-in mouse line”
Seminar at BCRM
Onur Basak will give a seminar on the 22nd of March 2018 at the David de Wied room on the 4th floor of Stratenum, at 9. The talk will be an introduction to of the past and present projects to the Translational Neuroscience department, and is titled “Modelling neural stem cell dynamics in space andContinue reading “Seminar at BCRM”
PNAS publication on adult neural stem cell dynamics
Adult mammalian tissues contain stem cells that contribute to tissue homeostasis and regeneration, with potential therapeutic applications. Specialized niches regulate their fate. Here we evaluated quantitatively how the subependymal zone niche regulates neural stem cell (NSC) number in the adult mouse brain. Using knock-in reporter alleles and single-cell RNA sequencing, we show that the WntContinue reading “PNAS publication on adult neural stem cell dynamics”
Deciphering the brain cell by cell
This is the excerpt for a featured post.
Basak lab 